Relation of Plasma Obestatin Levels to BMI, Gender, Age and Insulin.

Lippl, F; Erdmann, J; Lichter, N; Tholl, S; Wagenpfeil, S; Adam, O; Schusdziarra, V

doi:10.1055/s-2008-1081503

journal article

Dokumenttyp:: Journal Article; Article
Autor(en):: Lippl, F; Erdmann, J; Lichter, N; Tholl, S; Wagenpfeil, S; Adam, O; Schusdziarra, V
Titel:: Relation of Plasma Obestatin Levels to BMI, Gender, Age and Insulin.
Abstract:: Obestatin is supposed to be involved in nutrient homeostasis. Therefore, basal plasma obestatin levels were investigated in 321 normal weight and obese subjects in relation to body mass index, gender, age, insulin concentrations, and type 2 diabetes mellitus. Additionally, postprandial obestatin levels were determined in 20 normal weight subjects. Basal obestatin levels in females were higher compared to males (193.6+/-5.8 vs. 140.6+/-5.1 pg/ml). Obestatin levels correlated inversely and significantly with body mass index (f: r=-0.632, p<0.001; m: r=-0.487, p<0.001) and basal insulin levels (f: r=-0.536, p<0.001; m: r=-0.320, p=0.008) in females and males. However, in a multiple regression analysis as well as in a matched comparison of a low and high insulin group no significant relationship between insulin and obestatin levels was observed in nondiabetics. On the other hand, inclusion of type 2 diabetics with higher insulin levels resulted in a significant inverse correlation. Obestatin levels were independent of age in both sexes. In patients with type 2 diabetes mellitus basal obestatin levels were not different compared to nondiabetic subjects when matched for gender, body mass index, and insulin. In normal weight subjects, postprandial obestatin levels showed a significant decrease between 60 and 90 minutes rising to basal levels thereafter. The present data demonstrate a relation of plasma obestatin levels to body weight, gender and food intake, but not to age. The inverse relationship with insulin might depend on the level of hyperinsulinemia. The present data are compatible with a potential role of obestatin in nutrient regulation.
Zeitschriftentitel:: Horm Metab Res
Jahr:: 2008
Band / Volume:: 40
Heft / Issue:: 11
Seitenangaben Beitrag:: 806-12
Sprache:: eng
Volltext / DOI:: doi:10.1055/s-2008-1081503
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/18622896
Print-ISSN:: 0018-5043
TUM Einrichtung:: Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Institut für Medizinische Statistik und Epidemiologie
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