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Titel:

An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation.

Dokumenttyp:
Journal Article; Article
Autor(en):
Gross, C; Holler, E; Stangl, S; Dickinson, A; Pockley, AG; Asea, AA; Mallappa, N; Multhoff, G
Abstract:
In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell transplantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and in...     »
Zeitschriftentitel:
Leuk Res
Jahr:
2008
Band / Volume:
32
Heft / Issue:
4
Seitenangaben Beitrag:
527-34
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.leukres.2007.03.027
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17543383
Print-ISSN:
0145-2126
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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