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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article 
Author(s):
McAllister-Lucas, LM; Ruland, J; Siu, K; Jin, X; Gu, S; Kim, DS; Kuffa, P; Kohrt, D; Mak, TW; Nuñez, G; Lucas, PC 
Title:
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. 
Abstract:
Angiotensin II (Ang II) is a peptide hormone that, like many cytokines, acts as a proinflammatory agent and growth factor. After injury to the liver, the hormone assists in tissue repair by stimulating hepatocytes and hepatic stellate cells to synthesize extracellular matrix proteins and secrete secondary cytokines and by stimulating myofibroblasts to proliferate. However, under conditions of chronic liver injury, all of these effects conspire to promote pathologic liver fibrosis. Much of this e...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2007 
Journal volume:
104 
Journal issue:
Pages contribution:
139-44 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0027-8424 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)