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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
LeibundGut-Landmann, S; Gross, O; Robinson, MJ; Osorio, F; Slack, EC; Tsoni, SV; Schweighoffer, E; Tybulewicz, V; Brown, GD; Ruland, J; Reis e Sousa, C
Title:
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
Abstract:
The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the adaptor CARD9 to induce production of interleukin 10 (IL-10) and IL-2 in dendritic cells (DCs). However, whether this pathway promotes full DC activation remains unclear. Here we show that dectin-1-Syk-CARD9 signaling induced DC maturation and the secretion of proinflammatory cytokines, including IL-6, tumor necrosis factor and IL-23, but little IL-12. Dectin-1-activated DCs 'instructed' the differentiation of C...    »
Journal title abbreviation:
Nat Immunol
Year:
2007
Journal volume:
8
Journal issue:
6
Pages contribution:
630-8
Language:
eng
Fulltext / DOI:
doi:10.1038/ni1460
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17450144
Print-ISSN:
1529-2908
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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