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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Krötz, F; Keller, M; Derflinger, S; Schmid, H; Gloe, T; Bassermann, F; Duyster, J; Cohen, CD; Schuhmann, C; Klauss, V; Pohl, U; Stempfle, HU; Sohn, HY 
Title:
Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism. 
Abstract:
Endothelial dysfunction precedes hypertension and atherosclerosis and predicts cardiac allograft vasculopathy and death in heart transplant recipients. Endothelial overproduction of reactive oxygen species, such as superoxide anions produced by NAD(P)H oxidase, induces endothelial dysfunction. Because immunosuppressive drugs have been associated with increased reactive oxygen species production and endothelial dysfunction, we sought to elucidate the underlying mechanisms. Reactive oxygen species...    »
 
Journal title abbreviation:
Hypertension 
Year:
2007 
Journal volume:
49 
Journal issue:
Pages contribution:
201-8 
Language:
eng 
Print-ISSN:
0194-911X 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)