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Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Wessely, R; Blaich, B; BelAiba, RS; Merl, S; Gorlach, A; Kastrati, A; Schömig, A
Title:
Comparative characterization of cellular and molecular anti-restenotic profiles of paclitaxel and sirolimus. Implications for local drug delivery.
Abstract:
Pleiotropic anti-restenotic properties of drugs that are eluted from coated stents are critical for efficacy and safety. Little is known about comparative drug properties in appropriate human coronary target cell lines for the two compounds that are utilized on FDA-approved drug-eluting stent (DES) platforms, paclitaxel (PTX) and sirolimus (SRL). Target cell lines that play a pivotal role for the pathogenesis of restenosis and vascular healing include human coronary artery smooth muscle (CASMC)...    »
Journal title abbreviation:
Thromb Haemost
Year:
2007
Journal volume:
97
Journal issue:
6
Pages contribution:
1003-12
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17549304
Print-ISSN:
0340-6245
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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