User: Guest  Login
Title:

Glutamate induces apoptosis in cultured spiral ganglion explants.

Document type:
In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Steinbach, S; Lutz, J
Abstract:
Traumatic sound exposure, aminoglycoside antibiotics, cochlea ischemia or traumatic stress leads to an excessive release of glutamate from inner hair cells into the synaptic cleft. The high glutamate concentration can cause a swelling and destruction of the dendrites of spiral ganglion neurons of type I as well as a reduction in the number of neurons. This may be a cause of hearing loss. The mechanism causing the reduction of neurons is still not known. Apoptosis, also called programmed cell dea...     »
Journal title abbreviation:
Biochem Biophys Res Commun
Year:
2007
Journal volume:
357
Journal issue:
1
Pages contribution:
14-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.bbrc.2007.03.098
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17418815
Print-ISSN:
0006-291X
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann); Hals-Nasen-Ohrenklinik und Poliklinik
 BibTeX