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Title:

Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of spironolactone and losartan regarding long-term blood pressure and target organ damage.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Baumann, M; Hermans, JJ; Janssen, BJ; Peutz-Kootstra, C; Witzke, O; Heemann, U; Smits, JF; Boudier, HA
Abstract:
OBJECTIVE: We previously demonstrated that when the renin-angiotensin system (RAS) is transiently blocked by an angiotensin receptor blocker (ARB) in young spontaneously hypertensive rats (SHR), this results in a prolonged blood pressure decrease and protection against target organ damage. Aldosterone is an essential hormone in the RAS, and contributes to pathologic remodeling. Thus, part of the protective effects of the ARB may be due to inhibition of aldosterone-mediated effects. To test this...     »
Journal title abbreviation:
J Hypertens
Year:
2007
Journal volume:
25
Journal issue:
12
Pages contribution:
2504-11
Language:
eng
Fulltext / DOI:
doi:10.1097/HJH.0b013e3282ef84f8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17984673
Print-ISSN:
0263-6352
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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