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Titel:

Glutamate induces apoptosis in cultured spiral ganglion explants.

Dokumenttyp:
In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Steinbach, S; Lutz, J
Abstract:
Traumatic sound exposure, aminoglycoside antibiotics, cochlea ischemia or traumatic stress leads to an excessive release of glutamate from inner hair cells into the synaptic cleft. The high glutamate concentration can cause a swelling and destruction of the dendrites of spiral ganglion neurons of type I as well as a reduction in the number of neurons. This may be a cause of hearing loss. The mechanism causing the reduction of neurons is still not known. Apoptosis, also called programmed cell dea...     »
Zeitschriftentitel:
Biochem Biophys Res Commun
Jahr:
2007
Band / Volume:
357
Heft / Issue:
1
Seitenangaben Beitrag:
14-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.bbrc.2007.03.098
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17418815
Print-ISSN:
0006-291X
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann); Hals-Nasen-Ohrenklinik und Poliklinik
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