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Title:

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.

Document type:
In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Debela, M; Hess, P; Magdolen, V; Schechter, NM; Steiner, T; Huber, R; Bode, W; Goettig, P
Abstract:
hK7 or human stratum corneum chymotryptic enzyme belongs to the human tissue kallikrein (hKs) serine proteinase family and is strongly expressed in the upper layers of the epidermis. It participates in skin desquamation but is also implicated in diverse skin diseases and is a potential biomarker of ovarian cancer. We have solved x-ray structures of recombinant active hK7 at medium and atomic resolution in the presence of the inhibitors succinyl-Ala-Ala-Pro-Phe-chloromethyl ketone and Ala-Ala-Phe...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2007
Journal volume:
104
Journal issue:
41
Pages contribution:
16086-91
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.0707811104
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17909180
Print-ISSN:
0027-8424
TUM Institution:
Frauenklinik und Poliklinik
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