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Title:

The human airway trypsin-like protease modulates the urokinase receptor (uPAR, CD87) structure and functions.

Document type:
Journal Article
Author(s):
Beaufort, N; Leduc, D; Eguchi, H; Mengele, K; Hellmann, D; Masegi, T; Kamimura, T; Yasuoka, S; Fend, F; Chignard, M; Pidard, D
Abstract:
The human airway trypsin-like protease (HAT) is a respiratory epithelium-associated, type II transmembrane serine protease, which is also detected as an extracellular enzyme in lung fluids during airway inflammatory disorders. We have evaluated its capacity to affect the urokinase-type plasminogen activator receptor (uPAR), a membrane glycolipid-anchored, three-domain (D1D2D3) glycoprotein that plays a crucial role in innate immunity and inflammation by supporting cell migration and matrix degra...     »
Journal title abbreviation:
Am J Physiol Lung Cell Mol Physiol
Year:
2007
Journal volume:
292
Journal issue:
5
Pages contribution:
L1263-72
Language:
eng
Fulltext / DOI:
doi:10.1152/ajplung.00191.2006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17237151
Print-ISSN:
1040-0605
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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