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Title:

Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Radulescu, RT; Hufnagel, C; Luppa, P; Hellebrand, H; Kuo, WL; Rosner, MR; Harbeck, N; Giersig, C; Meindl, A; Schmitt, M; Weirich, G
Abstract:
Insulin is a hormone crucial to metabolism and an essential growth factor for normal and neoplastic tissues. We have now determined insulin in extracts of 23 primary breast cancer specimens and of non-neoplastic breast tissues by a chemiluminescent immunoassay. Remarkably, insulin was measured only in grade 3 tumors, whereas grade 2 carcinomas and the normal mammary gland were each insulin-negative. We also performed immunohistochemistry for insulin-degrading enzyme (IDE), a cytoplasmic zinc met...     »
Journal title abbreviation:
Int J Oncol
Year:
2007
Journal volume:
30
Journal issue:
1
Pages contribution:
73-80
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17143514
Print-ISSN:
1019-6439
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Klinische Chemie und Pathobiochemie
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