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Titel:

The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Krol, J; Francis, RE; Albergaria, A; Sunters, A; Polychronis, A; Coombes, RC; Lam, EW
Abstract:
Gefitinib is a specific inhibitor of the epidermal growth factor receptor (EGFR) that causes growth delay in cancer cell lines and human tumor xenografts expressing high levels of EGFR. An understanding of the downstream cellular targets of gefitinib will allow the discovery of biomarkers for predicting outcomes and monitoring anti-EGFR therapies and provide information for key targets for therapeutic intervention. In this study, we investigated the role of FOXO3a in gefitinib action and resista...     »
Zeitschriftentitel:
Mol Cancer Ther
Jahr:
2007
Band / Volume:
6
Heft / Issue:
12 Pt 1
Seitenangaben Beitrag:
3169-79
Sprache:
eng
Volltext / DOI:
doi:10.1158/1535-7163.MCT-07-0507
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18089711
Print-ISSN:
1535-7163
TUM Einrichtung:
Frauenklinik und Poliklinik
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