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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Harzenetter, MD; Novotny, AR; Gais, P; Molina, CA; Altmayr, F; Holzmann, B
Title:
Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER.
Abstract:
Communication between the nervous and immune systems involves the release of neuropeptides, such as calcitonin gene-related peptide (CGRP), from sensory nerves during inflammation. CGRP may inhibit the activities of both innate and adaptive immune cells, but the molecular pathways underlying this function are largely unknown. In this study, we identify CGRP as a potent inhibitor of TLR-stimulated production of inflammatory mediators, such as TNF-alpha and CCL4, by murine dendritic cells. Inhibit...    »
Journal title abbreviation:
J Immunol
Year:
2007
Journal volume:
179
Journal issue:
1
Pages contribution:
607-15
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17579082
Print-ISSN:
0022-1767
TUM Institution:
Chirurgische Klinik und Poliklinik
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