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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rohde, F; Rimkus, C; Friederichs, J; Rosenberg, R; Marthen, C; Doll, D; Holzmann, B; Siewert, JR; Janssen, KP
Title:
Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer.
Abstract:
Osteopontin (OPN) is a secreted phosphoprotein, which has been reported to be associated with tumor progression in numerous solid tumors. In a previous transcriptome study on colorectal cancer, we identified the gene OPN among the most strongly up-regulated transcripts. OPN has been suggested as a putative target of Wnt signaling, but the molecular mechanism responsible for its aberrant transcription is not fully understood. We analyzed 13 normal colon tissues, 9 adenomas, 120 primary colon tumo...    »
Journal title abbreviation:
Int J Cancer
Year:
2007
Journal volume:
121
Journal issue:
8
Pages contribution:
1717-23
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.22868
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17565744
Print-ISSN:
0020-7136
TUM Institution:
Chirurgische Klinik und Poliklinik
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