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Title:

Fusogenic vesicular stomatitis virus for the treatment of head and neck squamous carcinomas.

Document type:
In Vitro; Journal Article
Author(s):
Shin, EJ; Chang, JI; Choi, B; Wanna, G; Ebert, O; Genden, EM; Woo, SL
Abstract:
OBJECTIVES: This study investigates the efficacy of recombinant fusogenic VSV [rVSV-NDV/F(L289A) or rVSV-F] in the treatment of head and neck squamous cell carcinoma (HNSCC). STUDY DESIGN AND SETTING: The in vitro replication and cytotoxicity of rVSV-F were studied in two human SCC cell lines, in one murine SCC cell line, and in human keratinocytes. The effects on tumor size and animal survival were investigated following in vivo rVSV-F treatment of floor-of-mouth tumor model C3H/HeJ mice. RESULTS: Recombinant VSV-F preferentially induced rapid syncytia formation, and replicated in (P < 0.04) and killed (P < 1 x 10(-13)) all three SCC lines tested. The virus had no observable effect on human keratinocytes. Tumor size was smaller (P < 0.03) and overall survival was better (P < 0.001) for treated animals than for control animals. CONCLUSION/SIGNIFICANCE: Recombinant VSV-F confers a modest survival benefit for HNSCC in this orthotopic murine model. This oncolytic virus holds promise as a novel cancer treatment for recurrent HNSCC.
Journal title abbreviation:
Otolaryngol Head Neck Surg
Year:
2007
Journal volume:
136
Journal issue:
5
Pages contribution:
811-7
Language:
eng
Fulltext / DOI:
doi:10.1016/j.otohns.2006.11.046
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17478221
Print-ISSN:
0194-5998
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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