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Title:

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Kopitz, C; Gerg, M; Bandapalli, OR; Ister, D; Pennington, CJ; Hauser, S; Flechsig, C; Krell, HW; Antolovic, D; Brew, K; Nagase, H; Stangl, M; von Weyhern, CW; Brücher, BL; Brand, K; Coussens, LM; Edwards, DR; Kruger, A
Abstract:
Balanced expression of proteases and their inhibitors is one prerequisite of tissue homeostasis. Metastatic spread of tumor cells through the organism depends on proteolytic activity and is the death determinant for cancer patients. Paradoxically, increased expression of tissue inhibitor of metalloproteinases-1 (TIMP-1), a natural inhibitor of several endometalloproteinases, including matrix metalloproteinases and a disintegrin and metalloproteinase-10 (ADAM-10), in cancer patients is negatively...     »
Journal title abbreviation:
Cancer Res
Year:
2007
Journal volume:
67
Journal issue:
18
Pages contribution:
8615-23
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-07-0232
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17875701
Print-ISSN:
0008-5472
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Institut für Klinische Chemie und Pathobiochemie
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