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Titel:

Transcriptionally targeted nonviral gene transfer using a beta-catenin/TCF-dependent promoter in a series of different human low passage colon cancer cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gaedtke, L; Pelisek, J; Lipinski, KS; Wrighton, CJ; Wagner, E
Abstract:
Nonviral transfections of six low passage human colon cancer cell lines using the artificial beta-catenin/TCF-dependent promoter CTP4 demonstrated a high promoter activity which was 1000- to 70000-fold higher than in HeLa control cells. Luciferase gene expression levels obtained with CTP4 in epithelial-like tumor cell cultures were only slightly lower than with the strong viral CMV promoter/enhancer, whereas in less differentiated tumor cultures CTP4 expression levels exceeded the CMV expression...     »
Zeitschriftentitel:
Mol Pharm
Jahr:
2007
Band / Volume:
4
Heft / Issue:
1
Seitenangaben Beitrag:
129-39
Sprache:
eng
Volltext / DOI:
doi:10.1021/mp0600586
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17274670
Print-ISSN:
1543-8384
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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