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Titel:

Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Görgülü, Kivanc; Diakopoulos, Kalliope N; Ai, Jiaoyu; Schoeps, Benjamin; Kabacaoglu, Derya; Karpathaki, Angeliki-Faidra; Ciecielski, Katrin J; Kaya-Aksoy, Ezgi; Ruess, Dietrich A; Berninger, Alexandra; Kowalska, Marlena; Stevanovic, Marija; Wörmann, Sonja M; Wartmann, Thomas; Zhao, Yue; Halangk, Walter; Voronina, Svetlana; Tepikin, Alexey; Schlitter, Anna Melissa; Steiger, Katja; Artati, Anna; Adamski, Jerzy; Aichler, Michaela; Walch, Axel; Jastroch, Martin; Hartleben, Götz; Mantzoros, Christos...     »
Abstract:
BACKGROUND AND AIMS: Cells in pancreatic ductal adenocarcinoma (PDAC) undergo autophagy, but its effects vary with tumor stage and genetic factors. We investigated the consequences of varying levels of the autophagy related 5 (Atg5) protein on pancreatic tumor formation and progression. METHODS: We generated mice that express oncogenic Kras in primary pancreatic cancer cells and have homozygous disruption of Atg5 (A5; Kras) or heterozygous disruption of Atg5 (A5+/-; Kras), and compared them with...     »
Zeitschriftentitel:
Gastroenterology
Jahr:
2019
Band / Volume:
156
Heft / Issue:
1
Seitenangaben Beitrag:
203-217.e20
Sprache:
eng
Volltext / DOI:
doi:10.1053/j.gastro.2018.09.053
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30296435
Print-ISSN:
0016-5085
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Lehrstuhl für Tumormetabolismus (Prof. Algül)
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