The aim was to unravel a role of antibiotic on intestinal protease activity and associated adverse effects on the barrier function in the intestine and the colitis development in susceptible hosts. Increased protease activity is caused by the eradication of anti-proteolytic bacteria in the intestine in response to antibiotic. The high protease activity impairs intestinal barrier and accelerates colitis development in susceptible individuals, suggesting that the antibiotic-mediated high protease activity may be a risk factor for the development of Inflammatory bowel diseases.     «

The aim was to unravel a role of antibiotic on intestinal protease activity and associated adverse effects on the barrier function in the intestine and the colitis development in susceptible hosts. Increased protease activity is caused by the eradication of anti-proteolytic bacteria in the intestine in response to antibiotic. The high protease activity impairs intestinal barrier and accelerates colitis development in susceptible individuals, suggesting that the antibiotic-mediated high protease...     »