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Title:

Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bromberger, Thomas; Klapproth, Sarah; Sperandio, Markus; Moser, Markus
Abstract:
The use of cell-based reporter systems has provided valuable insights into the molecular mechanisms of integrin activation. However, current models have significant drawbacks because their artificially expressed integrins cannot be regulated by either physiological stimuli or endogenous signaling pathways. Here, we report the generation of a Hoxb8 cell line expressing human β2 integrin that functionally replaced the deleted mouse ortholog. Hoxb8 cells are murine hematopoietic progenitor cells th...     »
Journal title abbreviation:
Cells
Year:
2022
Journal volume:
11
Journal issue:
9
Fulltext / DOI:
doi:10.3390/cells11091532
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35563841
TUM Institution:
594; Experimentelle Hämatologie (Prof. Schmidt-Supprian)
 BibTeX