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Titel:

Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Bromberger, Thomas; Klapproth, Sarah; Sperandio, Markus; Moser, Markus
Abstract:
The use of cell-based reporter systems has provided valuable insights into the molecular mechanisms of integrin activation. However, current models have significant drawbacks because their artificially expressed integrins cannot be regulated by either physiological stimuli or endogenous signaling pathways. Here, we report the generation of a Hoxb8 cell line expressing human β2 integrin that functionally replaced the deleted mouse ortholog. Hoxb8 cells are murine hematopoietic progenitor cells th...     »
Zeitschriftentitel:
Cells
Jahr:
2022
Band / Volume:
11
Heft / Issue:
9
Volltext / DOI:
doi:10.3390/cells11091532
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35563841
TUM Einrichtung:
594; Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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