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Titel:

Hippo signaling in acute kidney injury to chronic kidney disease transition: Current understandings and future targets.

Dokumenttyp:
Journal Article; Review; Research Support, Non-U.S. Gov't
Autor(en):
Habshi, Tahib; Shelke, Vishwadeep; Kale, Ajinath; Lech, Maciej; Gaikwad, Anil Bhanudas
Abstract:
Acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition is a slow but persistent progression toward end-stage kidney disease. Earlier reports have shown that Hippo components, such as Yes-associated protein (YAP) and its homolog Transcriptional coactivator with PDZ-binding motif (TAZ), regulate inflammation and fibrogenesis during the AKI-to-CKD transition. Notably, the roles and mechanisms of Hippo components vary during AKI, AKI-to-CKD transition, and CKD. Hence, it is important t...     »
Zeitschriftentitel:
Drug Discov Today
Jahr:
2023
Band / Volume:
28
Heft / Issue:
8
Volltext / DOI:
doi:10.1016/j.drudis.2023.103649
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37268185
Print-ISSN:
1359-6446
TUM Einrichtung:
Professur für Nephrologie (Prof. Heemann)
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