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Document type:
Article; Journal Article
Author(s):
Renders, Lutz; Budde, Klemens; Rosenberger, Christian; van Swelm, Rachel; Swinkels, Dorine; Dellanna, Frank; Feuerer, Werner; Wen, Ming; Erley, Christiane; Bader, Birgit; Sommerer, Claudia; Schaier, Matthias; Meurer, Karoline; Matis, Louis
Title:
First-in-human Phase I studies of PRS-080#22, a hepcidin antagonist, in healthy volunteers and patients with chronic kidney disease undergoing hemodialysis.
Abstract:
In chronic kidney disease both renal insufficiency and chronic inflammation trigger elevated hepcidin levels, which impairs iron uptake, availability. and erythropoiesis. Here we report the two first-in-human phase 1 trials of PRS-080#22, a novel, rationally engineered Anticalin protein that targets and antagonizes hepcidin. A single intravenous infusion of placebo or PRS-080#22 was administered to 48 healthy volunteers (phase 1a) and 24 patients with end stage chronic kidney disease (CKD) on he...     »
Journal title abbreviation:
PLoS ONE
Year:
2019
Journal volume:
14
Journal issue:
3
Fulltext / DOI:
doi:10.1371/journal.pone.0212023
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30917125
Print-ISSN:
1932-6203
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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