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Title:

Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits.

Document type:
Article; Journal Article
Author(s):
Bryzek, Danuta; Ciaston, Izabela; Dobosz, Ewelina; Gasiorek, Anna; Makarska, Anna; Sarna, Michal; Eick, Sigrun; Puklo, Magdalena; Lech, Maciej; Potempa, Barbara; Potempa, Jan; Koziel, Joanna
Abstract:
Neutrophil-derived networks of DNA-composed extracellular fibers covered with antimicrobial molecules, referred to as neutrophil extracellular traps (NETs), are recognized as a physiological microbicidal mechanism of innate immunity. The formation of NETs is also classified as a model of a cell death called NETosis. Despite intensive research on the NETs formation in response to pathogens, the role of specific bacteria-derived virulence factors in this process, although postulated, is still poor...     »
Journal title abbreviation:
PLoS Pathog
Year:
2019
Journal volume:
15
Journal issue:
5
Fulltext / DOI:
doi:10.1371/journal.ppat.1007773
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31107907
Print-ISSN:
1553-7366
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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