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Titel:

A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Schwantes-An, Tae-Hwi; Whitfield, John B; Aithal, Guruprasad P; Atkinson, Stephen R; Bataller, Ramon; Botwin, Greg; Chalasani, Naga P; Cordell, Heather J; Daly, Ann K; Darlay, Rebecca; Day, Christopher P; Eyer, Florian; Foroud, Tatiana; Gawrieh, Samer; Gleeson, Dermot; Goldman, David; Haber, Paul S; Jacquet, Jean-Marc; Lammert, Craig S; Liang, Tiebing; Liangpunsakul, Suthat; Masson, Steven; Mathurin, Philippe; Moirand, Romain; McQuillin, Andrew; Moreno, Christophe; Morgan, Marsha Y; Mueller, Seb...     »
Abstract:
BACKGROUND: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-associated cirrhosis by comparing single-nucleotide polymorphisms among patients with alcohol-associated cirrhosis (ALC) versus drinkers who did not have evidence of liver fibrosis/cirrhosis. METHODS: Using a data-driven approach, a PRS for ALC was generated using a meta-genome-wide association...     »
Zeitschriftentitel:
Hepatol Commun
Jahr:
2024
Band / Volume:
8
Heft / Issue:
6
Volltext / DOI:
doi:10.1097/HC9.0000000000000431
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38727677
TUM Einrichtung:
Abteilung für Toxikologie (Prof. Eyer)
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