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Title:

Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers.

Document type:
Article; Journal Article
Author(s):
Stickel, Felix; Lutz, Philipp; Buch, Stephan; Nischalke, Hans Dieter; Silva, Ines; Rausch, Vanessa; Fischer, Janett; Weiss, Karl Heinz; Gotthardt, Daniel; Rosendahl, Jonas; Marot, Astrid; Elamly, Mona; Krawczyk, Marcin; Casper, Markus; Lammert, Frank; Buckley, Thomas W M; McQuillin, Andrew; Spengler, Ulrich; Eyer, Florian; Vogel, Arndt; Marhenke, Silke; von Felden, Johann; Wege, Henning; Sharma, Rohini; Atkinson, Stephen; Franke, Andre; Nehring, Sophie; Moser, Vincent; Schafmayer, Clemens; Spahr...     »
Abstract:
BACKGROUND AND AIMS: Carriage of rs738409:G in patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an increased risk for developing alcohol-related cirrhosis and hepatocellular carcinoma (HCC). Recently, rs72613567:TA in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) was shown to be associated with a reduced risk for developing alcohol-related liver disease and to attenuate the risk associated with carriage of PNPLA3 rs738409:G. This study explores the risk association...     »
Journal title abbreviation:
Hepatology
Year:
2020
Journal volume:
72
Journal issue:
1
Pages contribution:
88-102
Fulltext / DOI:
doi:10.1002/hep.30996
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31630428
Print-ISSN:
0270-9139
TUM Institution:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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