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Title:

L-Arginine in the treatment of valproate overdose - five clinical cases.

Document type:
Case Reports; Journal Article; Observational Study
Author(s):
Schrettl, Verena; Felgenhauer, Norbert; Rabe, Christian; Fernando, Malkanthi; Eyer, Florian
Abstract:
Valproic acid and its metabolites - particularly valproyl-CoA - are inhibitors of the enzyme N-acetylglutamate synthetase. The amino acid l-arginine can stimulate N-acetylglutamate synthetase activity and could be potentially used therapeutically to correct hyperammonemia caused by valproate therapy or overdose. Severely valproic-acid-poisoned patients are usually treated with l-carnitine or hemodialysis in order to decrease hyperammonemia. We herein report of five cases, in which l-arginine was...     »
Journal title abbreviation:
Clin Toxicol (Phila)
Year:
2017
Journal volume:
55
Journal issue:
4
Pages contribution:
260-266
Language:
eng
Fulltext / DOI:
doi:10.1080/15563650.2017.1284333
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28152637
Print-ISSN:
1556-3650
TUM Institution:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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