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Title:

Genetic insights into resting heart rate and its role in cardiovascular disease.

Document type:
Meta-Analysis; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
van de Vegte, Yordi J; Eppinga, Ruben N; van der Ende, M Yldau; Hagemeijer, Yanick P; Mahendran, Yuvaraj; Salfati, Elias; Smith, Albert V; Tan, Vanessa Y; Arking, Dan E; Ntalla, Ioanna; Appel, Emil V; Schurmann, Claudia; Brody, Jennifer A; Rueedi, Rico; Polasek, Ozren; Sveinbjornsson, Gardar; Lecoeur, Cecile; Ladenvall, Claes; Zhao, Jing Hua; Isaacs, Aaron; Wang, Lihua; Luan, Jian'an; Hwang, Shih-Jen; Mononen, Nina; Auro, Kirsi; Jackson, Anne U; Bielak, Lawrence F; Zeng, Linyao; Shah, Nabi; Neth...     »
Abstract:
Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously ident...     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-39521-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37532724
Print-ISSN:
2041-1723
TUM Institution:
1379; 606; 656; Institut für Humangenetik (Prof. Winkelmann); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)
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