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Title:
Osteoporosis Is the Most Important Risk Factor for Odontoid Fractures in the Elderly.
Document type:
Clinical Trial; Journal Article
Author(s):
Kaesmacher, Johannes; Schweizer, Claudia; Valentinitsch, Alexander; Baum, Thomas; Rienmüller, Anna; Meyer, Bernhard; Kirschke, Jan S; Ryang, Yu-Mi
Abstract:
Traumatic odontoid fractures (TOFs) have been described as the most common injury affecting the C-spine in the elderly. Previous studies have identified degenerative changes and bone loss as important predisposing factors. However, their interaction and respective age-adjusted impact needs further clarification. We conducted a retrospective analysis of 5303 patients (aged >=60 years) admitted to a level I trauma center between January 2008 and January 2016 who underwent CT imaging of the C-spine. Ninety-two patients with TOF and 80 patients with other cervical spine fractures (OCSF) were identified and a respective 3:1 age- and sex-matched control group without fractures after trauma was built. In all groups, cervical bone mineral density (cBMD) was determined using phantom calibration, and degenerative changes were evaluated in a qualitative manner. In all groups, the severity of degenerative changes of the C-spine increased with age (all p < 0.05) and was inversely correlated with cBMD (all p < 0.05). cBMD was the only significant predictor of a TOF in a multivariate logistic regression model (adjusted odds ratio [OR] = 3.066, 95% confidence interval [CI] 1.432-6.563 for cervical osteoporosis). An association between odontoid cysts and TOF reached significance only in Anderson and D'Alonzo (A&D) type II TOFs (aOR = 1.383; 95% CI 1.012-1.890). Patients with OCSFs, compared with patients with TOFs, were younger (median 74 versus 83 years) and had a higher cBMD (median 208 mg/mL versus 172 mg/mL). No differences were observable when comparing cBMD and grades of degenerative changes between OCSFs and their control group (all p >0.1). Decreased cBMD is the major predisposing factor for the occurrence of TOF but not for OCSF in the elderly. The severity of odontoid cysts was found to be a cBMD-independent factor associated with A&D type II TOFs. However, degenerative changes in the odontoid neighboring joints seem to be an epiphenomenon of bone loss and older age but do not independently predispose for TOF. © 2017 American Society for Bone and Mineral Research.
Journal title abbreviation:
J Bone Miner Res
Year:
2017
Journal volume:
32
Journal issue:
7
Pages contribution:
1582-1588
Language:
eng
Fulltext / DOI:
doi:10.1002/jbmr.3120
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28256741
Print-ISSN:
0884-0431
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Neurochirurgische Klinik und Poliklinik
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mediaTUM Gesamtbestand
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TUM School of Medicine and Health
Departments
Clinical Medicine
Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)
Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)
Professur für Neuroradiologie (Prof. Zimmer)
2017
mediaTUM Gesamtbestand
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TUM School of Medicine and Health
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Klinik und Poliklinik für Neurochirurgie (Prof. Meyer)
2017
mediaTUM Gesamtbestand
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2017
Fakultäten
Medizin
Institut für Radiologie