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Title:

Card9 controls Dectin-1-induced T-cell cytotoxicity and tumor growth in mice.

Document type:
Journal Article; Article
Author(s):
Haas, Tobias; Heidegger, Simon; Wintges, Alexander; Bscheider, Michael; Bek, Sarah; Fischer, Julius C; Eisenkolb, Gabriel; Schmickl, Martina; Spoerl, Silvia; Peschel, Christian; Poeck, Hendrik; Ruland, Jürgen
Abstract:
Activation of the C-type lectin receptor Dectin-1 by ?-glucans triggers multiple signals within DCs that result in activation of innate immunity. While these mechanisms can potently prime CD8(+) cytotoxic T-cell (CTL) responses without additional adjuvants, the Dectin-1 effector pathways that control CTL induction remain unclear. Here we demonstrate that Dectin-1-induced CTL cross-priming in mice does not require inflammasome activation but strictly depends on the adapter protein Card9 in vitro....     »
Journal title abbreviation:
Eur J Immunol
Year:
2017
Journal volume:
47
Journal issue:
5
Pages contribution:
872-879
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.201646775
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28295265
Print-ISSN:
0014-2980
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie
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