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Title:

A microsatellite based multiplex PCR method for the detection of chromosomal instability in gastric cancer.

Document type:
Journal Article
Author(s):
Kohlruss, Meike; Reiche, Magdalena; Jesinghaus, Moritz; Grosser, Bianca; Slotta-Huspenina, Julia; Hapfelmeier, Alexander; Bauer, Lukas; Novotny, Alexander; Weichert, Wilko; Keller, Gisela
Abstract:
Chromosomal instability (CIN) is a hallmark of distinct subclasses of tumours with potential clinical relevance. The aim of our study was to establish a time and cost effective method for the determination of CIN in gastric carcinomas (GC). We developed a microsatellite based multiplex PCR assay for the detection of allelic imbalances (AI) using experimentally defined marker specific threshold values for AI. The assay was tested in 90 formalin-fixed paraffin-embedded GC and results were compared...     »
Journal title abbreviation:
Sci Rep
Year:
2018
Journal volume:
8
Journal issue:
1
Pages contribution:
12551
Language:
eng
Fulltext / DOI:
doi:10.1038/s41598-018-30971-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30135548
Print-ISSN:
2045-2322
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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