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Title:

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.

Document type:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Article
Author(s):
Macé, Aurélien; Tuke, Marcus A; Deelen, Patrick; Kristiansson, Kati; Mattsson, Hannele; Nõukas, Margit; Sapkota, Yadav; Schick, Ursula; Porcu, Eleonora; Rüeger, Sina; McDaid, Aaron F; Porteous, David; Winkler, Thomas W; Salvi, Erika; Shrine, Nick; Liu, Xueping; Ang, Wei Q; Zhang, Weihua; Feitosa, Mary F; Venturini, Cristina; van der Most, Peter J; Rosengren, Anders; Wood, Andrew R; Beaumont, Robin N; Jones, Samuel E; Ruth, Katherine S; Yaghootkar, Hanieh; Tyrrell, Jessica; Havulinna, Aki S; Boer...     »
Abstract:
There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to 191,161 adult samples from 26 cohorts. The study reveals five CNV associations at 1q21.1, 3q29, 7q11.23, 11p14.2, and 18q21.32 and confirms two known loci at 16p11.2 and 22q11.21, implicating at least one anthropometric trait. The discovered CNVs are recurrent and rare (0.01-0.2%),...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Journal issue:
1
Pages contribution:
744
Language:
eng
Fulltext / DOI:
doi:10.1038/s41467-017-00556-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28963451
Print-ISSN:
2041-1723
TUM Institution:
Institut für Humangenetik
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