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Titel:

A dual role for hepatocyte-intrinsic canonical NF-?B signaling in virus control.

Dokumenttyp:
Journal Article; Article
Autor(en):
Namineni, Sukumar; O'Connor, Tracy; Faure-Dupuy, Suzanne; Johansen, Pål; Riedl, Tobias; Liu, Kaijing; Xu, Haifeng; Singh, Indrabahadur; Shinde, Prashant; Li, Fanghui; Pandyra, Aleksandra; Sharma, Piyush; Ringelhan, Marc; Muschaweckh, Andreas; Borst, Katharina; Blank, Patrick; Lampl, Sandra; Neuhaus, Katharina; Durantel, David; Farhat, Rayan; Weber, Achim; Lenggenhager, Daniela; Kündig, Thomas M; Staeheli, Peter; Protzer, Ulrike; Wohlleber, Dirk; Holzmann, Bernhard; Binder, Marco; Breuhahn, Kai;...     »
Abstract:
Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resident macrophages. However, hepatocytes, the parenchymal cells of the liver, also possess potent immunological functions in addition to their known metabolic functions. Owing to their abundance in the liver and known immunological functions, we aimed to investigate the direct antiviral mechanisms employed by hepatocytes.Using lymphocytic choriomeningitis virus (LCMV) as a model of liver i...     »
Zeitschriftentitel:
J Hepatol
Jahr:
2020
Band / Volume:
72
Heft / Issue:
5
Seitenangaben Beitrag:
960-975
Volltext / DOI:
doi:10.1016/j.jhep.2019.12.019
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31954207
Print-ISSN:
0168-8278
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Experimentelle Onkologie und Therapieforschung; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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