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Titel:

Targeting of Magnetic Nanoparticle-coated Microbubbles to the Vascular Wall Empowers Site-specific Lentiviral Gene Delivery .

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Heun, Yvonn; Hildebrand, Staffan; Heidsieck, Alexandra; Gleich, Bernhard; Anton, Martina; Pircher, Joachim; Ribeiro, Andrea; Mykhaylyk, Olga; Eberbeck, Dietmar; Wenzel, Daniela; Pfeifer, Alexander; Woernle, Markus; Krötz, Florian; Pohl, Ulrich; Mannell, Hanna
Abstract:
In the field of vascular gene therapy, targeting systems are promising advancements to improve site-specificity of gene delivery. Here, we studied whether incorporation of magnetic nanoparticles (MNP) with different magnetic properties into ultrasound sensitive microbubbles may represent an efficient way to enable gene targeting in the vascular system after systemic application. Thus, we associated novel silicon oxide-coated magnetic nanoparticle containing microbubbles (SO-Mag MMB) with lentivi...     »
Zeitschriftentitel:
Theranostics
Jahr:
2017
Band / Volume:
7
Heft / Issue:
2
Seitenangaben Beitrag:
295-307
Sprache:
eng
Volltext / DOI:
doi:10.7150/thno.16192
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28042335
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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