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Title:

Analysis of immune responses in patients with CLL after heterologous COVID-19 vaccination.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
Author(s):
Lee, Hye Kyung; Hoechstetter, Manuela A; Buchner, Maike; Pham, Trang Thu; Huh, Jin Won; Müller, Katharina; Zange, Sabine; von Buttlar, Heiner; Girl, Philipp; Wölfel, Roman; Brandmeier, Lisa; Pfeuffer, Lisa; Furth, Priscilla A; Wendtner, Clemens-Martin; Hennighausen, Lothar
Abstract:
Patients with chronic lymphocytic leukemia (CLL) treated with B-cell pathway inhibitors and anti-CD20 antibodies exhibit low humoral response rates following SARS-CoV-2 vaccination. To investigate this observation, a prospective single-institution study was conducted comparing peripheral blood mononuclear cell transcriptional response with antibody and T-cell response rates following heterologous BNT162b2/ChAdOx1 vaccination of 15 patients with CLL/small lymphocytic lymphoma (SLL). Two-dose anti...     »
Journal title abbreviation:
Blood Adv
Year:
2023
Journal volume:
7
Journal issue:
10
Pages contribution:
2214-2227
Fulltext / DOI:
doi:10.1182/bloodadvances.2022008445
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36630562
Print-ISSN:
2473-9529
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland)
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