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Titel:

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using (111)In-tilmanocept.

Dokumenttyp:
Journal Article
Autor(en):
Varasteh, Zohreh; Hyafil, Fabien; Anizan, Nadège; Diallo, Devy; Aid-Launais, Rachida; Mohanta, Sarajo; Li, Yuanfang; Braeuer, Miriam; Steiger, Katja; Vigne, Jonathan; Qin, Zhengtao; Nekolla, Stephan G; Fabre, Jean-Etienne; Döring, Yvonne; Le Guludec, Dominique; Habenicht, Andreas; Vera, David R; Schwaiger, Markus
Abstract:
Atherosclerotic plaque phenotypes are classified based on the extent of macrophage infiltration into the lesions, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The mannose receptor (MR) is over-expressed in activated macrophages. Tilmanocept is a tracer that targets MR and is approved in Europe and the USA for the detection of sentinel lymph nodes. In this study, our aim was to evaluate the potential of (111)In-labelled tilmanocept for the detection of...     »
Zeitschriftentitel:
EJNMMI Res
Jahr:
2017
Band / Volume:
7
Heft / Issue:
1
Seitenangaben Beitrag:
40
Sprache:
eng
Volltext / DOI:
doi:10.1186/s13550-017-0287-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28470406
Print-ISSN:
2191-219X
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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