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Title:

The Oncolytic Adenovirus XVir-N-31 Joins Forces with CDK4/6 Inhibition Augmenting Innate and Adaptive Antitumor Immunity in Ewing Sarcoma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schober, Sebastian Johannes; Schoening, Caroline; Eck, Jennifer; Middendorf, Charlotte; Lutsch, Julia; Knoch, Pia; von Ofen, Anna Josefine; Gassmann, Hendrik; Thiede, Melanie; Hauer, Julia; Kolk, Andreas; Mantwill, Klaus; Gschwend, Jürgen E; Burdach, Stefan E G; Nawroth, Roman; Thiel, Uwe; Holm, Per Sonne
Abstract:
PURPOSE: Ewing sarcoma (EwS) is a highly malignant pediatric tumor characterized by a non-T-cell-inflamed immune-evasive phenotype. When relapsed or metastasized, survival is poor, emphasizing the need for novel treatment strategies. Here, we analyze the novel combination approach using the YB-1-driven oncolytic adenovirus XVir-N-31 and CDK4/6 inhibition to augment EwS immunogenicity. EXPERIMENTAL DESIGN: In vitro, viral toxicity, replication, and immunogenicity were studied in several EwS cell...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2023
Journal volume:
29
Journal issue:
10
Pages contribution:
1996-2011
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-22-1961
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36892582
Print-ISSN:
1078-0432
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Kinder- und Jugendmedizin (Prof. Hauer); Klinik und Poliklinik für Urologie (Prof. Gschwend)
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