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Title:

Cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells involves p53 and Hsp70.

Document type:
Journal Article
Author(s):
Wang, Fei; Dezfouli, Ali Bashiri; Khosravi, Mohammad; Sievert, Wolfgang; Stangl, Stefan; Schwab, Melissa; Wu, Zhiyuan; Steiger, Katja; Ma, Hu; Multhoff, Gabriele
Abstract:
Although it has been established that cannabidiol (CBD), the major non-psychoactive constituent of cannabis, exerts antitumoral activities, the exact mechanism(s) via which tumor cells are killed by CBD are not well understood. This study provides new insights into the potential mechanisms of CBD-induced mutual antagonism of apoptosis and macroautophagy using wild type (HCT116 p53wt, LS174T p53wt), knockout (HCT116 p53-/-) and mutant (SW480 p53mut) human colorectal cancer cells (CRC). CBD causes...     »
Journal title abbreviation:
Cell Death Discov
Year:
2023
Journal volume:
9
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41420-023-01578-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37542074
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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