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Titel:

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.

Dokumenttyp:
Journal Article
Autor(en):
Dettmar, Larissa; Ahmed, Nancy; Kotzsch, Matthias; Diersch, Sandra; Napieralski, Rudolf; Darmoul, Dalila; Schmitt, Manfred; Weichert, Wilko; Kiechle, Marion; Dorn, Julia; Magdolen, Viktor
Abstract:
Gene expression of a variety of the 15 members of the KLK serine protease family is dysregulated in ovarian cancer. We aimed at determining the clinical relevance of KLK13 and KLK14 mRNA expression in tumor tissues of a homogeneous patient cohort afflicted with advanced high-grade serous ovarian cancer (FIGO stage III/IV).mRNA expression levels of KLK13 and KLK14 were assessed by quantitative PCR in tumor tissue of 91 patients and related with clinical factors and patients' outcome.There was no...     »
Zeitschriftentitel:
J Cancer Res Clin Oncol
Jahr:
2018
Band / Volume:
144
Heft / Issue:
6
Seitenangaben Beitrag:
1109-1118
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00432-018-2623-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29546479
Print-ISSN:
0171-5216
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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