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Title:

Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.

Document type:
Journal Article; Article
Author(s):
Patel, Vivek L; Busch, Evan L; Friebel, Tara M; Cronin, Angel; Leslie, Goska; McGuffog, Lesley; Adlard, Julian; Agata, Simona; Agnarsson, Bjarni A; Ahmed, Munaza; Aittomäki, Kristiina; Alducci, Elisa; Andrulis, Irene L; Arason, Adalgeir; Arnold, Norbert; Artioli, Grazia; Arver, Brita; Auber, Bernd; Azzollini, Jacopo; Balmana, Judith; Barkardottir, Rosa B; Barnes, Daniel R; Barroso, Alicia; Barrowdale, Daniel; Belotti, Muriel; Benitez, Javier; Bertelsen, Brigitte; Blok, Marinus J; Bodrogi, Istvan...     »
Abstract:
Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly assoc...     »
Journal title abbreviation:
Cancer Res
Year:
2020
Journal volume:
80
Journal issue:
3
Pages contribution:
624-638
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-19-1840
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31723001
Print-ISSN:
0008-5472
TUM Institution:
1072; 597; Frauenklinik und Poliklinik
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