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Title:

tRNA-derived small RNA 3'U-tRFValCAC promotes tumour migration and early progression in ovarian cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Panoutsopoulou, Konstantina; Magkou, Paraskevi; Dreyer, Tobias; Dorn, Julia; Obermayr, Eva; Mahner, Sven; van Gorp, Toon; Braicu, Ioana; Magdolen, Viktor; Zeillinger, Robert; Avgeris, Margaritis; Scorilas, Andreas
Abstract:
INTRODUCTION: Despite recent advances in epithelial ovarian cancer (EOC) management, the highly heterogenous histological/molecular tumour background and patients' treatment response obstructs personalised prognosis and therapeutics. Herein, we have studied the role and clinical utility of the novel subclass of tRNA-derived small RNA fragments emerging via 3'-trailer processing of pre-tRNAs (3'U-tRFs) in EOC. METHODS: SK-OV-3 and OVCAR-3 cells were used for in vitro study. Following transfection...     »
Journal title abbreviation:
Eur J Cancer
Year:
2023
Journal volume:
180
Pages contribution:
134-145
Fulltext / DOI:
doi:10.1016/j.ejca.2022.11.033
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36599181
Print-ISSN:
0959-8049
TUM Institution:
597; Klinik und Poliklinik für Frauenheilkunde (Prof. Kiechle)
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