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Titel:

An NF-?B Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; 3
Autor(en):
Oh, Hyunju; Grinberg-Bleyer, Yenkel; Liao, Will; Maloney, Dillon; Wang, Pingzhang; Wu, Zikai; Wang, Jiguang; Bhatt, Dev M; Heise, Nicole; Schmid, Roland M; Hayden, Matthew S; Klein, Ulf; Rabadan, Raul; Ghosh, Sankar
Abstract:
Both conventional T (Tconv) cells and regulatory T (Treg) cells are activated through ligation of the T cell receptor (TCR) complex, leading to the induction of the transcription factor NF-?B. In Tconv cells, NF-?B regulates expression of genes essential for T cell activation, proliferation, and function. However the role of NF-?B in Treg function remains unclear. We conditionally deleted canonical NF-?B members p65 and c-Rel in developing and mature Treg cells and found they have unique but par...     »
Zeitschriftentitel:
Immunity
Jahr:
2017
Band / Volume:
47
Heft / Issue:
3
Seitenangaben Beitrag:
450-465.e5
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.immuni.2017.08.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28889947
Print-ISSN:
1074-7613
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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