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Title:

Verification of organophosphorus pesticide poisoning: Detection of phosphorylated tyrosines and a cysteine-proline disulfide-adduct from human serum albumin after intoxication with dimethoate/omethoate.

Document type:
Journal Article
Author(s):
Kranawetvogl, Andreas; Siegert, Markus; Eyer, Florian; Thiermann, Horst; John, Harald
Abstract:
A method is described allowing forensic analysis of plasma samples to prove human poisoning with the organophosphorus pesticides omethoate (OM) and dimethoate (DIM). Upon incubation of human serum albumin (HSA) with both pesticides tyrosine residues were phosphorylated. In addition, a novel disulfide-adduct between the identical thiol-containing leaving group of OM and DIM (2-mercapto-N-methylacetamide, MNMA) and the only free cysteine residue in HSA (Cys) was formed. Following pronase-catalyzed...     »
Journal title abbreviation:
Toxicol Lett
Year:
2018
Journal volume:
299
Pages contribution:
11-20
Language:
eng
Fulltext / DOI:
doi:10.1016/j.toxlet.2018.08.013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30165092
Print-ISSN:
0378-4274
TUM Institution:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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