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Titel:

Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Dobosz, Ewelina; Lorenz, Georg; Ribeiro, Andrea; Würf, Vivian; Wadowska, Marta; Kotlinowski, Jerzy; Schmaderer, Christoph; Potempa, Jan; Fu, Mingui; Koziel, Joanna; Lech, Maciej
Abstract:
Myeloid-derived cells, in particular macrophages, are increasingly recognized as critical regulators of the balance of immunity and tolerance. However, whether they initiate autoimmune disease or perpetuate disease progression in terms of epiphenomena remains undefined.Here, we show that depletion of MCPIP1 in macrophages and granulocytes (Mcpip1fl/fl-LysMcre+ C57BL/6 mice) is sufficient to trigger severe autoimmune disease. This was evidenced by the expansion of B cells and plasma cells and spo...     »
Zeitschriftentitel:
Dis Model Mech
Jahr:
2021
Band / Volume:
14
Heft / Issue:
3
Volltext / DOI:
doi:10.1242/dmm.047589
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33737335
Print-ISSN:
1754-8403
TUM Einrichtung:
602; Fachgebiet Nephrologie (Prof. Heemann)
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