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Titel:

A toolbox for microbore liquid chromatography tandem-high-resolution mass spectrometry analysis of albumin-adducts as novel biomarkers of organophosphorus pesticide poisoning.

Dokumenttyp:
Case Reports; Journal Article
Autor(en):
von der Wellen, Jens; Winterhalter, Peter; Siegert, Markus; Eyer, Florian; Thiermann, Horst; John, Harald
Abstract:
Exposure to toxic organophosphorus pesticides (OPP) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks. Therefore, reliable verification procedures for OPP-intoxications are required for forensic, toxicological and clinical reasons. We developed and optimized a toolbox of methods to detect adducts of human serum albumin (HSA) with OPP considered as long-term biomarkers. Human serum was incubated with diethyl-oxono and diethyl-thiono pesticides...     »
Zeitschriftentitel:
Toxicol Lett
Jahr:
2018
Band / Volume:
292
Seitenangaben Beitrag:
46-54
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.toxlet.2018.04.025
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29702198
Print-ISSN:
0378-4274
TUM Einrichtung:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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