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Title:

The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation.

Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Dzulko, Melanie; Pons, Miriam; Henke, Andreas; Schneider, Günter; Krämer, Oliver H
Abstract:
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase. This enzyme is involved in a plethora of cellular processes, including apoptosis, autophagy, cell proliferation, and DNA repair. Remarkably, PP2A can act as a context-dependent tumor suppressor or promoter. Active PP2A complexes consist of structural (PP2A-A), regulatory (PP2A-B), and catalytic (PP2A-C) subunits. The regulatory subunits define the substrate specificity and the subcellular localization of the holoenzyme. Here...     »
Journal title abbreviation:
BBA - REVIEWS ON CANCER
Year:
2020
Journal volume:
1874
Journal issue:
2
Fulltext / DOI:
doi:10.1016/j.bbcan.2020.188453
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33068647
Print-ISSN:
0304-419X
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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