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Document type:
Journal Article
Author(s):
Triebelhorn, Julian; Cardon, Iseline; Kuffner, Kerstin; Bader, Stefanie; Jahner, Tatjana; Meindl, Katrin; Rothhammer-Hampl, Tanja; Riemenschneider, Markus J; Drexler, Konstantin; Berneburg, Mark; Nothdurfter, Caroline; Manook, André; Brochhausen, Christoph; Baghai, Thomas C; Hilbert, Sven; Rupprecht, Rainer; Milenkovic, Vladimir M; Wetzel, Christian H
Title:
Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties.
Abstract:
The molecular pathomechanisms of major depressive disorder (MDD) are still not completely understood. Here, we follow the hypothesis, that mitochondria dysfunction which is inevitably associated with bioenergetic disbalance is a risk factor that contributes to the susceptibility of an individual to develop MDD. Thus, we investigated molecular mechanisms related to mitochondrial function in induced neuronal progenitor cells (NPCs) which were reprogrammed from fibroblasts of eight MDD patients and...     »
Journal title abbreviation:
Mol Psychiatry
Year:
2024
Journal volume:
29
Journal issue:
5
Pages contribution:
1217-1227
Fulltext / DOI:
doi:10.1038/s41380-022-01660-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35732695
Print-ISSN:
1359-4184
TUM Institution:
Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)
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