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Title:

DOTA-Based Plectin-1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue.

Document type:
Journal Article
Author(s):
Gazzi, Thais; Lesina, Marina; Wang, Qinghua; Berninger, Alexandra; Radetzki, Silke; Demir, Ihsan Ekin; Heinemann, Larissa; Meiser, Waldemar; Wilke, Sebastian; Peter von Kries, Jens; Algül, Hana; Hu, Hai-Yu; Nazaré, Marc
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal malignancy with extremely poor patient survival rates. A key reason for the poor prognosis is the lack of effective diagnostic tools to detect the disease at curable, premetastatic stages. Tumor surgical resection is PDAC's first-line treatment, however distinguishing between cancerous and healthy tissue with current imaging tools remains a challenge. In this work, we report a DOTA-based fluorescent probe targeting plectin...     »
Journal title abbreviation:
Angew Chem Int Ed Engl
Year:
2024
Journal volume:
63
Journal issue:
26
Fulltext / DOI:
doi:10.1002/anie.202318485
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38608197
Print-ISSN:
1433-7851
TUM Institution:
Lehrstuhl für Tumormetabolismus (Prof. Algül)
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