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Title:

A toolbox for microbore liquid chromatography tandem-high-resolution mass spectrometry analysis of albumin-adducts as novel biomarkers of organophosphorus pesticide poisoning.

Document type:
Case Reports; Journal Article
Author(s):
von der Wellen, Jens; Winterhalter, Peter; Siegert, Markus; Eyer, Florian; Thiermann, Horst; John, Harald
Abstract:
Exposure to toxic organophosphorus pesticides (OPP) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks. Therefore, reliable verification procedures for OPP-intoxications are required for forensic, toxicological and clinical reasons. We developed and optimized a toolbox of methods to detect adducts of human serum albumin (HSA) with OPP considered as long-term biomarkers. Human serum was incubated with diethyl-oxono and diethyl-thiono pesticides...     »
Journal title abbreviation:
Toxicol Lett
Year:
2018
Journal volume:
292
Pages contribution:
46-54
Language:
eng
Fulltext / DOI:
doi:10.1016/j.toxlet.2018.04.025
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29702198
Print-ISSN:
0378-4274
TUM Institution:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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